Predictors of positive axillary lymph nodes after sentinel lymph node biopsy in breast cancer
Identifieur interne : 009D84 ( Main/Exploration ); précédent : 009D83; suivant : 009D85Predictors of positive axillary lymph nodes after sentinel lymph node biopsy in breast cancer
Auteurs : Shahab F. Abdessalam [États-Unis] ; Emmanuel E. Zervos [États-Unis] ; Manju Prasad [États-Unis] ; William B. Farrar [États-Unis] ; Lisa D. Yee [États-Unis] ; Michael J. Walker [États-Unis] ; William B. Carson [États-Unis] ; William E. Burak Jr [États-Unis]Source :
- The American Journal of Surgery [ 0002-9610 ] ; 2001.
English descriptors
Abstract
Objective: The purpose of this study was to determine the factors that predict the presence of metastasis in nonsentinel lymph nodes (SLN) when the SLN is positive.Methods: A prospective database was analyzed and included patients who underwent SLN biopsy for invasive breast cancer from July 1997 to August 2000 (n = 442). One hundred (22.6%) patients had one or more positive SLNs, and were analyzed to determine factors that predicted additional positive axillary nodes.Results: Of the 100 patients with a positive SLN, 40 patients (40%) had additional metastasis in non-SLNs. The only significant variables that predicted non-SLN metastasis were tumor lymphovascular invasion (P = 0.004), extranodal extension (P <0.001), and increasing size of the metastasis within the SLN (P = 0.011). In analyzing just those patients who had lymphovascular invasion, extranodal extension, and a SLN metastasis >2mm, 92% were found to have additional positive nodes.Conclusions: In patients with invasive breast cancer and a positive sentinel lymph node, lymphovascular invasion, extranodal extension, and increasing size of the metastasis all significantly increase the frequency of additional positive nodes.
Url:
DOI: 10.1016/S0002-9610(01)00719-X
Affiliations:
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James Cancer Hospital and Solove Research Institute, Ohio State University, Columbus, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Carson, William B" sort="Carson, William B" uniqKey="Carson W" first="William B" last="Carson">William B. Carson</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Surgery, Division of Surgical Oncology, Arthur G. James Cancer Hospital and Solove Research Institute, Ohio State University, Columbus, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Burak Jr, William E" sort="Burak Jr, William E" uniqKey="Burak Jr W" first="William E" last="Burak Jr">William E. 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One hundred (22.6%) patients had one or more positive SLNs, and were analyzed to determine factors that predicted additional positive axillary nodes.Results: Of the 100 patients with a positive SLN, 40 patients (40%) had additional metastasis in non-SLNs. The only significant variables that predicted non-SLN metastasis were tumor lymphovascular invasion (P = 0.004), extranodal extension (P <0.001), and increasing size of the metastasis within the SLN (P = 0.011). In analyzing just those patients who had lymphovascular invasion, extranodal extension, and a SLN metastasis >2mm, 92% were found to have additional positive nodes.Conclusions: In patients with invasive breast cancer and a positive sentinel lymph node, lymphovascular invasion, extranodal extension, and increasing size of the metastasis all significantly increase the frequency of additional positive nodes.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Ohio</li></region></list><tree><country name="États-Unis"><region name="Ohio"><name sortKey="Abdessalam, Shahab F" sort="Abdessalam, Shahab F" uniqKey="Abdessalam S" first="Shahab F" last="Abdessalam">Shahab F. Abdessalam</name></region><name sortKey="Burak Jr, William E" sort="Burak Jr, William E" uniqKey="Burak Jr W" first="William E" last="Burak Jr">William E. Burak Jr</name><name sortKey="Burak Jr, William E" sort="Burak Jr, William E" uniqKey="Burak Jr W" first="William E" last="Burak Jr">William E. Burak Jr</name><name sortKey="Burak Jr, William E" sort="Burak Jr, William E" uniqKey="Burak Jr W" first="William E" last="Burak Jr">William E. Burak Jr</name><name sortKey="Carson, William B" sort="Carson, William B" uniqKey="Carson W" first="William B" last="Carson">William B. Carson</name><name sortKey="Farrar, William B" sort="Farrar, William B" uniqKey="Farrar W" first="William B" last="Farrar">William B. Farrar</name><name sortKey="Prasad, Manju" sort="Prasad, Manju" uniqKey="Prasad M" first="Manju" last="Prasad">Manju Prasad</name><name sortKey="Walker, Michael J" sort="Walker, Michael J" uniqKey="Walker M" first="Michael J" last="Walker">Michael J. Walker</name><name sortKey="Yee, Lisa D" sort="Yee, Lisa D" uniqKey="Yee L" first="Lisa D" last="Yee">Lisa D. Yee</name><name sortKey="Zervos, Emmanuel E" sort="Zervos, Emmanuel E" uniqKey="Zervos E" first="Emmanuel E" last="Zervos">Emmanuel E. Zervos</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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